Applications: WB, ELISA, FCM
Reactivity: Human, Mouse, Rat
Predicted reactivity: Dog, Cow, Pig, Horse, Chicken
| OVERVIEW | |
| CATALOG # | bs-8257R |
| PRODUCT NAME | TBX1 Polyclonal Antibody |
| APPLICATIONS | WB, ELISA, FCM |
| REACTIVITY | Human, Mouse, Rat |
| PREDICTED REACTIVITY | Dog, Cow, Pig, Horse, Chicken |
| SPECIFICATIONS | |
| CONJUGATION | Unconjugated |
| HOST | Rabbit |
| SOURCE | KLH conjugated synthetic peptide derived from human TBX1 |
| IMMUNOGEN RANGE | 165-270/398 |
| CLONALITY | Polyclonal |
| ISOTYPE | IgG |
| CONCENTRATION | 1ug/ul |
| PURIFICATION | Purified by Protein A. |
| STORAGE BUFFER | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| STORAGE CONDITION | Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| TARGET | |
| GENE ID | 6899 |
| SUBCELLULAR LOCATION | Nucleus |
| SYNONYMS | Brachyury; CAFS; CTHM; DGCR; DGS; DORV; T box 1; T box 1 transcription factor; T box 1 transcription factor C; T box; T box protein 1; T box transcription factor TBX 1; T box transcription factor TBX1; T-box 1; T-box protein 1; T-box transcription factor TBX1; TBX 1; TBX 1C; tbx1; TBX1_HUMAN; TBX1C; Testis specic T box protein; Testis-specic T-box protein; TGA; VCFS. |
| BACKGROUND | Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries.Involvement in disease:Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) . DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defects, cleft palate or velar insufficiency, facial dysmorpholgy and learning difficulties. It is now accepted that these two syndromes represent two forms of clinical expression of the same entity manifesting at different stages of life.Defects in TBX1 are a cause of DiGeorge syndrome (DGS) .Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) .Defects in TBX1 are a cause of conotruncal heart malformations (CTHM). CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies. |
| APPLICATION DILUTION | |
| WB | 1:300-5000 |
| ELISA | 1:500-1000 |
| FCM | 1:20-100 |